Endocrine Abstracts

Context: Cushing’s disease (CD) results from the release of high levels of adrenocorticotrophic hormone (ACTH) from a pituitary adenoma. Increased ACTH secretion stimulates excess cortisol production, causing weight gain, hypertension, diabetes and depression. The only curative treatment is transsphenoidal surgery, but the rate of recurrence is high and there is a lack of suitable medical therapies. RNA-interference is a mechanism of post-transcriptional gene silencing th...